Background: Researchers have developed several equations to predict glomerular filtration rate (GFR) in patients\nwith chronic kidney diseases (CKD). However, there are scarcely any studies performed to discern the best equation\nto estimate GFR in patients with pure obstructive nephropathy. In present study, we assessed the suitability of six\nprediction equations and compared their performance in eGFR evaluation for Chinese patients with obstructive\nnephropathy.\nMethods: A total of 245 adult patients with obstructive nephropathy were enrolled. We evaluated the performance\nof the 3 Modification of Diet in Renal Disease equations (MDRD) (the original MDRD7, 7MDRD; the abbreviated\nMDRD, aMDRD; and re-expressed abbreviated MDRD, re-aMDRD) and 3 Chronic Kidney Disease Epidemiology\nCollaboration equations (CKD-EPI) (CKD-EPI equation based on creatinine alone, CKD-EPIcr; CKD-EPI equation based\non cystatin C alone, CKD-EPIcys; CKD-EPI equation based on combined creatinine-cystatin, CKD-EPIcr-cys). The\nmeasured GFR (mGFR) by 99mTc-DTPA renal dynamic imaging method was used as the reference GFR.\nResults: The mean age of the study population was 51.61 Ã?± 14.17 and 131 were male (53.47 %). The mean\nmeasured GFR was 66.54 Ã?± 23.99 ml/min/1.73 m2. Overall, the CKD-EPIcr-cys equation gave the best performance\nwith the best correlation (R = 0.72) and agreement (âË?â??34.87, 40.83). CKD-EPIcr-cys equation also exhibited the highest\naccuracy (69.39 %, P < 0.01) and diagnostic efficacy (ROCAUC = 0.874) with the smallest bias (2.98, P < 0.01). In the\nsubgroup of the lowest GFR, CKD-EPIcys equation exhibited the highest accuracy (52.69 %) and the smallest bias\n(0.27). In the youngest age subgroup, CKD-EPIcys equation had the highest accuracy (71.64 %) and the smallest bias\n(âË?â??1.24). In other subgroups stratified by GFR, age and gender, CKD-EPIcr-cys equation remained the best\nperformance.\nConclusion: The 3 CKD-EPI equations performed better than the 3 MDRD equations in estimating GFR in Chinese\nobstructive nephropathy patients; while the CKD-EPI equation based on combined creatinine-cystatin C provided\nthe best estimation of GFR.
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